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New Research Alert - Dr Morgan Farley
Exercise has been consistently shown to reduce the risk of cancer development, cancer recurrence, and mortality - but a question I am consistently asked is how?
In a new publication Dr Morgan Farley founder of Valere Health provides evidence to support one of the mechanisms thought to be behind the beneficial effects of exercise on cancer growth.
Exercise has been shown in pre-clinical (mouse models) to suppress cancer growth and blood taken immediately post exercise from breast, prostate, colorectal, and lung cancer survivors has been shown to suppress cancer growth (Orange et al. 2020).
Additionally, exercise was shown to increase responsiveness to immunotherapy in mouse models of pancreatic cancer (Kurz et al. 2022).
In this research it is thought that the exercise induced release of cells (myokines) called IL-15 and IL-6 are among the key factors responsible for the exercise induced suppression of cancer growth. However the response of these factors was yet to be elucidated in human cancer survivors.
Therefore, this research aimed to explore the response of these myokines to high intensity exercise.
We found a 50-100% increase in myokines that have been liked to improved cancer outcomes specifically IL-15 immediately post exercise!
What does this mean for you
Exercise that increases your heart rate can increase circulating factors known to be associated with suppression of cancer growth and treatment responsiveness
Shorter more frequent bouts at intensities that get your heart rate up (you should be breathless)
Aim for short periods 30s-4minutes of exercise that increases heart rate with periods of rest in between e.g.,
jogging on the spot
dancing
cycling
hill walking
Check out the video to learn more
If you are not sure where to start - call Valere Health today 0439 542 036 or book an initial assessment today
References
Orange ST, Jordan AR, Saxton JM. The serological responses to acute exercise in humans reduce cancer cell growth in vitro: A systematic review and meta-analysis. Physiol Rep. 2020; 8:e14635. https://doi.org/10.14814/phy2.14635
Kurz E, Hirsch CA, Dalton T, Shadaloey SA, Khodadadi-Jamayran A, Miller G, Pareek S, Rajaei H, Mohindroo C, Baydogan S, Ngo-Huang A, Parker N, Katz MHG, Petzel M, Vucic E, McAllister F, Schadler K, Winograd R, Bar-Sagi D. Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer. Cancer Cell. 2022 Jul 11;40(7):720-737.e5. doi: 10.1016/j.ccell.2022.05.006. Epub 2022 Jun 2. PMID: 35660135; PMCID: PMC9280705.
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